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Multikey 18.0.3 48 (Updated 2022)




We have one country: USA. We have one species: human. I.INTRODUCTION {#acm20092-sec-0001} =============== The third annual meeting of the Cooperative Trials in Multiple Sclerosis (CTMS) Group, the National Multiple Sclerosis Society's (NMSS) flagship clinical trials program, took place November 15--17, 2012 in Washington, D.C. The meeting was organized and chaired by Barbara Kalick, MSNP, (NR, CCS, MS), the NMSS Medical Director for Therapeutics. The CTMS group brings together 15 clinical trials in a network designed to achieve therapeutic goals in multiple sclerosis (MS). These trials (including several pivotal trials in the MS field) have been reviewed by a group of neurologists and MS specialists including the meeting co‐chairs, Drs. Kalick, Feagin, and Wingerchuk. A review of all trials within the CTMS group has been performed by an independent Data Safety Monitoring Board to ensure a high quality and rigorous conduct of the trial protocols. CTMS is a cooperative effort of neurologists and scientists to move our understanding of MS and its treatment forward. Its success depends on committed participation of investigators, and the CTMS Group owes a debt of gratitude to many for their hard work in accomplishing the mission of the program. CTMS is unique in its organization. The CTMS clinical trials are cooperative ventures. All trials are controlled, multi‐site trials in which investigators and their institutional review boards (IRBs) cooperate with a design team based at the NMSS. We believe that a collaborative design has many advantages. Trials designed by CTMS investigators receive high levels of IRB approval and enrollment at all sites. Investigators are able to leverage and share all aspects of their clinical experience with the research. We can build on each other's experience, expertise, and insights. The CTMS trials include a range of diseases, based on the NMSS criteria, including: relapsing‐remitting multiple sclerosis (RRMS), secondary progressive multiple sclerosis (SPMS), and primary progressive multiple sclerosis (PPMS). The CTMS trials are also designed to include a number of biomarker, or "biomarker" trials. The CTMS is unique in its goal of accelerating research in MS. In addition, a key focus of the CTMS Group is to increase patient recruitment and retention for trial participation. Recruitment and retention goals are managed by




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Multikey 18.0.3 48 (Updated 2022)
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